ibutilide (Selleck Chemicals)
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93
Structured Review
Selleck Chemicals
ibutilide
Ibutilide, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ibutilide/Gabapentin/pm35125346-163-0-7
Average 93 stars, based on 4 article reviews
Ibutilide, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ibutilide/Gabapentin/pm35125346-163-0-7
Average 93 stars, based on 4 article reviews
ibutilide - by Bioz Stars,
2026-09
93/100 stars
Images
1) Product Images from "A High-Throughput Screening Assay to Identify Drugs that Can Treat Long QT Syndrome Caused by Trafficking-Deficient K V 11.1 (hERG) Variants."
Article Title: A High-Throughput Screening Assay to Identify Drugs that Can Treat Long QT Syndrome Caused by Trafficking-Deficient K V 11.1 (hERG) Variants.
Journal: Molecular pharmacology
doi: 10.1124/molpharm.121.000421
Figure Legend Snippet: Fig. 8. Optimized Tl1 flux assay detected increased KV11.1-G601S-G965*X trafficking with three known KV11.1 inhibitors. (A) Bar graph show- ing Tl1 flux Z scores after 24-hour treatment with E-4031. 56 wells were selected from central rows of the plate as representative of control. Dot- ted black line indicates threshold for “hit” selection set to Z score $ 3. (B) Western blot showing increased fully glycosylated protein (mature), representative of increased KV11.1 protein trafficking after 24-hour treatment with 10 mM azelastine, azaperone, or ibutilide. All wells loaded with 20 mg of protein. (C) Western blot showing increased KV11.1 protein trafficking after 24 hours of treatment with 10 mM azelastine, azaper- one, or ibutilide in HEK-293 cells expressing KV11.1-N470D and KV11.1-G601S. All wells loaded with 20 mg of protein. (D) Whole cell current recordings at 120 mV step. Representative current traces (left) and bar graphs (right) depicting KV11.1-G601S-G965*X current after 24-hour incubation with 10 mM drug and washout before experiments. Inset shows enlarged current traces at 120 mV voltage step. N 5 8 for E-4031 treatment and n 5 7 for all other treatments. Treated samples compared with vehicle control (0.1% DMSO) by one-way ANOVA with post hoc Dunnett’s t test. Bars on scatter plots represent mean of each group. * 5 P < 0.05. Veh. 5 0.1% DMSO, E-4. 5 E-4031, Azel. 5 azelastine, Azap. 5 azaperone, and Ibu. 5 ibutilide.
Techniques Used: Flux Assay, Control, Selection, Western Blot, Expressing, Incubation
Related Articles
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Article Snippet: The positive control used in all 24-hour incubation experiments, E-4031, was purchased as dry powder from Cayman Chemicals.The positive control used in all 24-hour incubation experiments, E-4031, was purchased as dry powder from Cayman Chemicals.. Ibutilide, Article Title: Evaluating class III antiarrhythmic agents as novel MYC targeting drugs in ovarian cancer Article Snippet: Phosphate-buffered saline (PBS) was purchased from Corning.Phosphate-buffered saline (PBS) was purchased from Corning.. Amiodarone, dronedarone, Selection:Article Title: A High-Throughput Screening Assay to Identify Drugs that Can Treat Long QT Syndrome Caused by Trafficking-Deficient K V 11.1 (hERG) Variants. Article Snippet: The positive control used in all 24-hour incubation experiments, E-4031, was purchased as dry powder from Cayman Chemicals.The positive control used in all 24-hour incubation experiments, E-4031, was purchased as dry powder from Cayman Chemicals.. Ibutilide, Article Title: Evaluating class III antiarrhythmic agents as novel MYC targeting drugs in ovarian cancer Article Snippet: Phosphate-buffered saline (PBS) was purchased from Corning.Phosphate-buffered saline (PBS) was purchased from Corning.. Amiodarone, dronedarone, Western Blot:Article Title: A High-Throughput Screening Assay to Identify Drugs that Can Treat Long QT Syndrome Caused by Trafficking-Deficient K V 11.1 (hERG) Variants. Article Snippet: The positive control used in all 24-hour incubation experiments, E-4031, was purchased as dry powder from Cayman Chemicals.The positive control used in all 24-hour incubation experiments, E-4031, was purchased as dry powder from Cayman Chemicals.. Ibutilide, Article Title: Evaluating class III antiarrhythmic agents as novel MYC targeting drugs in ovarian cancer Article Snippet: Phosphate-buffered saline (PBS) was purchased from Corning.Phosphate-buffered saline (PBS) was purchased from Corning.. 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